Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Mar; 21(3): 203-5.

[Effect of guizhi decoction on adenyl cyclase and phosphodiesterase in hypothalamus of rats models of fever and hypothermia]

Qi Y, Huo HR, Tian JL.

Institute of Chinese Materia Medica, China Academy of TCM, Beijing 100700.

OBJECTIVE: To observe the effect of Guizhi Decoction (GZD) on adenyl cyclase (AC) and phosphodiesterase (PDE) activities in hypothalamus of rat models of fever and hypothermia. METHODS: The AC and PDE activities in hypothalamus were determined using radio-isotope method. RESULTS: GZD could lower the AC activity in yeast induced fever rat model (P < 0.05), but cause rise of AC activity in aminopyrine induced hypothermia model (P < 0.05). No significant influence of GZD on PDE activity was shown in both fever or hypothermia models. CONCLUSION: The bi-directional thermo-regulation effect of GZD might be partially due to influence on AC activity.