Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Oct; 21(10): 736-8.

[Clinical study on regulatory effect of liandai Capsule on p21ras and mutant p53 protein expression in gastrointestinal neoplasm]

Yang CB, Chen WW, Wang JH.

Piwei-Institute, Guangzhou University of TCM, Guangzhou 510407.

OBJECTIVE: To study the regulatory effect of Liandai Capsule on p21ras and mutant p53 protein expression in gastrointestinal (GI) neoplasm. METHODS: Forty-five patients of GI neoplasm in middle or advanced stage were enrolled and divided randomly into the treated group and the control group to observe the changes of their serum p21ras and mutant p53 protein expression as well as their quality of life (QOL) before and after treatment. RESULTS: The content of p21ras and mutant p53 protein expression in the treated group decreased significantly and QOL improved after treatment, P < 0.05 or P < 0.01, while these changes in the control group were not shown. CONCLUSION: Liandai Capsule has regulatory effect on p21ras and mutant p53 protein expression in GI neoplasm.