Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Dec; 21(12): 903-5.

[Clinical observation of compound salvia injection in treating mid-severe infantile hypoxic-ischemic encephalopathy]

Jiang FX, Wang SJ, Zhong L.

Dongguan Municipal Donghua Hospital, Guangdon 523000.

OBJECTIVE: To observe the changes of endothelin-1 (ET-1), nitrogen oxide (NO) and creatine phosphokinase BB isozyme (CK-BB) in blood and cerebrospinal fluid (CSF) in patients of infantile hypoxic-ishemic encephalopathy (HIE), and explore the efficacy of compound Salvia injection (CSI) in treating mid-severe HIE. METHODS: Sixty mid-severe infantile HIE patients were divided randomly into the treated and the control group. To the treated group CSI was added on the basis of conventional treatment, and to the control group the conventional treatment was given alone. The blood and CSF content of ET-1, NO and CK-BB at acute and convalescent stage in the two groups were determined and the therapeutic effects were compared between the two groups. RESULTS: The markedly effective rate and effective rate of the treated group was 80.0% and 93.3% respectively, while that of the control group was 66.7% and 83.3% respectively, the therapeutic effect in the treated group were obviously superior to that in the control group, the difference was significant (P < 0.05). CONCLUSION: ET-1, NO and CK-BB participated the pathological process of HIE. CSI was markedly effective in treating mid and severe HIE infants.