Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Sep; 21(9): 667-9.

[Effect of yiqi bushen huoxue herbs in treating children asthma and on levels of nitric oxide, endothelin-1 and serum endothelial cells]

Kong LF, Guo LH, Zheng XY.

Jining Municipal First People's Hospital, Shandong 272011.

OBJECTIVE: To observe the therapeutic effect of Yiqi Bushen Huoxue herbs (YQBSHX, the Chinese herbs for supplementing Qi, replenishing Kidney and activating blood circulation) on children asthma in regard to its effect on the serum levels of nitric oxide (NO), endothelin-1 (ET-1) and circulating endothelial cells (CEC). METHODS: Two hundred children with asthma were divided into two groups, the YQBSHX and the control group, and their serum levels of NO, ET-1 and CEC were detected in acute and remission stage respectively. Twenty cases in each group were followed-up for 1 year to observe the frequency of asthma attack and the changes in ET-1, NO and CEC levels. RESULTS: Serum levels of ET-1, NO and CEC in patients of acute stage were obviously raised. After treatment, the above-mentioned criteria in the YQBSHX group were significantly lower than those in the control group (P < 0.01). And the frequency of attack in the YQBSHX group was markedly reduced. CONCLUSION: YQBSHX herbs could reduce ET-1, NO and CEC levels in children asthma, lessen the frequency of attack, therefore, to elevate the cure rate of children asthma.