Eksp Klin Farmakol. 2001 Nov-Dec; 64(6): 45-7.

[Effect of Rhaponticum carthamoides extract on hemorheological properties of blood in rats with arterial hypertension]

Plotnikov MB, Aliev OI, Vasil'ev AS, Maslov MIu, Dmitruk SE, Krasnov EA.

Laboratory of Circulatory, Tomsk Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.

The hemorheological activity of a dry extract from Rhaponticum (Leuzea) carthamoides (Willd.) Iljin. was studied in spontaneously hypertensive rats (SHRs). A 14-day treatment of the test rats with a daily dose of 150 mg/kg improved the rheological characteristics, as manifested by a reduced viscosity of the whole blood and plasma, increased spontaneous erythrocyte aggregation and fibrinogen concentration, and increased erythrocyte deformability and electrophoretic mobility against the untreated control level.