Therapie. 2001 Sep-Oct; 56(5): 595-600.

[Protective effects of a Ginkgo biloba extract (EGb 761) on ischemia-reperfusion injury]

Clostre F.

EGb 761 is a standardized extract of dried leaves of Ginkgo biloba. EGb 761 is a neuroprotective and anti-ischaemic drug. Its broad spectrum of pharmacological activities allows it to be adequate to the numerous pathological requirements--haemodynamic, haemorrheological, metabolic--which occur in cerebral, retinal, cochleovestibular, cardiac or peripheral ischaemia. Moreover, EGb 761 has direct effects in retinal and myocardial ischaemia and reperfusion injuries. EGb 761 improves retinal microcirculation, reduces oedema of the retinal inner layer and protects chemoreceptors against free-radical injuries. On myocardial ischaemia-reperfusion models, EGb 761 improves myocardial functional recovery, and reduces the number of ventricular extrasytoles and the duration of ventricular tachycardia induced by reperfusion. EGb 761 protects the retina and the heart against ischaemia-reperfusion damage via its free radical-scavenging and anti-lipoperoxidative properties and its regulation of mitochondrial respiratory function.