Phytother Res. 2001 Nov; 15(7): 643-5.

Protective role of Bacopa monniera on morphine induced hepatotoxicity in rats.

Sumathy T, Subramanian S, Govindasamy S, Balakrishna K, Veluchamy G.

Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, Tamilnadu, India.

The protective effect of Bacopa monniera on morphine induced liver antioxidant levels was studied in rats. Oral administration of alcohol extracts of Bacopa monniera induced a significant hepatoprotective effect. In the morphine treated group, a significant increase of lipid peroxidation and a significant decrease in liver antioxidant enzyme levels were observed. Simultaneous administration of morphine and Bacopa extract prevented these alterations. The results of this study showed that Bacopa monniera alcohol extract exerted a hepatoprotective effect against morphine induced liver toxicity.Copyright 2001 John Wiley & Sons, Ltd.