Phytother Res. 2001 Nov; 15(7): 630-2.

Experimental treatment of chronic Trypanosoma cruzi infection in mice with 2-n-propylquinoline.

Nakayama H, Ferreira ME, Rojas de Arias A, Vera de Bilbao N, Torres S, Schinini A, Fournet A.

Instituto de Investigaciones en Ciencias de la Salud, Department of Tropical Medicine, Casilla de Correo 2511, AsunciÃ³n, Paraguay.

It was reported previously that 2-n-propylquinoline was active against the epimastigote form of Trypanosoma cruzi. The effects of oral treatments with benznidazole and 2-n-propylquinoline were evaluated in Balb/c mice infected with T. cruzi chronically. The reference drug and 2-n-propylquinoline were administered 60 days post-infection for 30 days at 25 mg/mL. At 35 days post-treatment, the serological tests (ELISA) of the 2-n- propylquinoline-treated mice were significantly different from the controls (p = 0.01) and the benznidazole-treated mice (p = 0.03), while this was not the case at 85 days post-treatment. These results are encouraging for continuing the investigation of other analogues of 2-n-propylquinoline in experimental chronic Chagas' disease.Copyright 2001 John Wiley & Sons, Ltd.