Planta Med. 2001 Nov; 67(8): 743-4.

Phenolic compounds with anti-inflammatory activity from Eupatorium buniifolium.

Muschietti L, Gorzalczany S, Ferraro G, Acevedo C, Martino V.

CÃ¡tedra de Farmacognosia, IQUIMEFA (UBA-CONICET), Facultad de Farmacia y BioquÃmica, Universidad de Buenos Aires, Buenos Aires, Argentina. [email protected]

Anti-inflammatory activity was detected in the CH(2)Cl(2) extract of the aerial parts of Eupatorium buniifolium using the TPA-mouse ear model. Three compounds isolated from this extract, by bioassay-guided fractionation, significantly inhibited the inflammatory response. The compounds were identified as 5,7,5'-trihydroxy-3,6,2',4'-tetramethoxyflavone (1), scopoletin (2) and centaureidin (3) which inhibited the edema by 67.3 %, 59.8 % and 49.7 %, respectively, at a dose of 1 mg/ear.