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December 2024

Fitoterapia. 2001 Dec; 72(8): 887-93.

An anti-inflammatory and immunomodulatory polysaccharide from Orbignya phalerata.

da Silva BP, Parente JP.

Laboratório de Química de Plantas Medicinais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, P.O. Box 68045, CEP 21944-970, Rio de Janeiro, Brazil.

A polysaccharide, a glucan with mean M(r) of 1.0 x 10(6) (MP1), was isolated from the mesocarp of fruits of Orbignya phalerata. Chemical and spectroscopic studies indicated that MP1 has a highly branched glucan type structure composed of alpha-(1-->4) linked D-glucopyranose residues with (3-->4), (4-->6), and with (3-->6) branching points. MP1 enhanced phagocytosis in vivo and exhibited anti-inflammatory activity.


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