Zhong Yao Cai. 2001 Aug; 24(8): 588-9.

[Protective effect of tanshinone IIA on acute hepatic injury in mice]

Liu Y, Chen H, Jiang Y.

First Military Medical University, Guangzhou 510515.

OBJECTIVE: To study the effect of tanshinone IIA on two models of acute hepatic injury in mice. METHODS: Two acute hepatic injury models induced by carbon tetrachloride (CCl4) and D-galactosamine (D-GalN) in mice were used. ALT, AST in serum and MDA in liver homogenate were used as indexes. RESULTS: Tanshinone IIA (10 mg.kg-1, 20 mg.kg-1, 30 mg.kg-1), similar to biophenyldicarboxylate, could decrease ALT, AST in serum and MDA in hepatic homogenate on acute hepatic injury induced by CCl4 and D-GalN. CONCLUSION: Tanshinone IIA possessed obvious protective effect against liver injury induced by CCl4 or D-GalN.