Therapie. 2001 Jul-Aug; 56(4): 431-4.

Chemical composition and analgesic activity of Calophyllum brasiliense leaves.

da Silva KL, dos Santos AR, Mattos PE, Yunes RA, Delle-Monache F, Cechinel-Filho V.

NÃºcleo de InvestigaÃ§Ãµes QuÃmico-FarmacÃªuticas (NIQFAR)/CCS, Universidade do Vale de ItajaÃ (UNIVALI), Rua Uruguai No. 458, C. Posta 88302-202, ItajaÃ SC, Brazil.

This paper describes a phytochemical and pharmacological study with Calophyllum brasiliense leaves, a medicinal plant employed in folk medicine for the treatment of several ailments. Based on spectroscopic evidence, five phenolic compounds were identified as hyperin (hyperoside), amentoflavone, quercetin, gallic acid, and protocatechuic acid. The fractions and some phenolic compounds exhibited significant analgesic activity against the writhing test and in relation to the second phase (inflammatory pain) of the formalin test in mice, suggesting that this plant can be useful for the treatment of dolorous processes.