Eksp Klin Farmakol. 2001 Jul-Aug; 64(4): 59-62.

[Effect of gamma-linolenic acid on microsomal oxidation in the rat liver following gamma-irradiation]

Zavodnik LB, Sushko LI, Tarasov IuA, Ignatenko KV, Chumachenko SS, Ovchinnikov VA, Brzosko V, Buko VU.

Laboratory of Experimental Hepatology, Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno, 230017 Belarus.

The antioxidant and radioprotector properties of gamma-linolenic acid isolated from the seeds of Borago officialis were studied on rats gamma-irradiated to a dose of 1 Gy. The irradiation caused an increase in the content of malonaldehyde in microsomal liver fraction and disturbed the metabolism of xenobiotics. The administration of gamma-linolenic acid in the form of a commercial drug Neoglandin (daily dose, 150 mg/kg, p.o.; over 1, 3, or 7 days after irradiation reduced the level of lipid peroxidation (for all treatment schedules), normalized the activity of NADPH-oxidase, NADH-oxidase, and NADPH-reductase, and increased the content of cytochromes P-450 and b5 as compared to bothirradiated and control animals.