Fitoterapia. 2001 Aug; 72(6): 676-9.

A novel cytotoxic flavonoid glycoside from Physalis angulata.

Ismail N, Alam M.

College of Pharmacy, University of Houston, 4800 Calhoun, Houston, TX 77204-5515, USA. [email protected]

A new flavonol glycoside, myricetin 3-O-neohesperidoside (1) was isolated from a cytotoxic MeOH extract of the leaves of Physalis angulata. Compound 1 showed remarkable cytotoxicity in vitro against murine leukemia cell line P-388, epidermoid carcinoma of the nasopharynx KB-16 cells, and lung adenocarcinoma A-549 with ED(50) values of 0.048, 0.50 and 0.55 microg ml(-1), respectively.