Phytother Res. 2001 Sep; 15(6): 544-8.

Neuroprotective effects of Withania somnifera Dunn. in hippocampal sub-regions of female albino rat.

Jain S, Shukla SD, Sharma K, Bhatnagar M.

Department of Zoology, University College of Science, M.L. Sukhadia University, Udaipur 313001, India.

The neuroprotective effects of W. somnifera were studied on stressed adult female Swiss albino rats. Experimental rats were subjected to immobilization stress for 14 h and were treated with a root powder extract of W. somnifera available as Stresscom capsules (Dabur India Ltd). Control rats were maintained in completely, non stressed conditions. Thionin stained serial coronal sections (7 microm) of brain passing through the hippocampal region of stressed rats (E(1) group) demonstrated 85% degenerating cells (dark cells and pyknotic cells) in the CA(2) and CA(3) sub-areas. Treatment with W. somnifera root powder extract significantly reduced (80%) the number of degenerating cells in both the areas. The study thus demonstrates the antistress neuroprotective effects of W. somnifera.Copyright 2001 John Wiley & Sons, Ltd.