Phytomedicine. 2001 Jul; 8(4): 298-301.

Evaluation of anti-tussive activity of Bergenia ciliata Sternb. rhizome extract in mice.

Sinha S, Murugesan T, Pal M, Saha BP.

Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.

The methanol extract of the rhizome of Bergenia ciliata Sternb. (Saxifragaceae) has been evaluated for its potential in a cough model induced by sulphur dioxide gas in mice. The extract exhibited significant anti-tussive activity in a dose-dependent manner, as compared with control. The antitussive activity of the extract was comparable to that of codeine phosphate (10 mg/kg body wt.), a standard anti-tussive agent. The extract at doses of 100, 200 and 300 mg/kg body wt. (p.o.) showed significant inhibition of cough reflex by 28.7, 33.9 and 44.2%, respectively, within 90 min of the experiment.