Zhonghua Gan Zang Bing Za Zhi. 2001 Jul; 9 Suppl(): 34-6.

[Effect of Xue Zhi Kang on the formation of fatty liver in cholesterol-fed rabbits]

Zhang M, Tong Y, Zheng X, Chen Y.

Department of Cardiology, the Central Affiliated Hospital, Shenyang Medical University, Shenyang 110024, China.

OBJECTIVE: To explore the effect of Xue Zhi Kang (XZhK) on the formation of fatty liver in cholesterol-fed rabbits. METHODS: XZhK was refined from Chinese traditional medicine Hong Qu and its main composition is HMG-CoA reductase inhibitor. Thirty New Zealand white rabbits were randomly assigned into 3 groups (control, hypercholesterol-fed, and XZhK groups) during the 12 week's experiment. The effects of XZhK (0.8g.kg(-1).d(-1)) were investigated in rabbits fed a l.5% cholesterol diet. The changes of serum TC, TG, HDL-C, and LDL-C concentrations and the histopathological changes of the liver were detected. RESULTS: The serum TC, LDL-C, and TG levels decreased in XZhK group compared with those in the cholesterol-fed control group (P<0.05 ). The serum HDL-C concentration slightly increased, but there was no statistical significance. The fatty degeneration of liver was ameliorated in XZhK group (P<0.05). CONCLUSIONS: XZhK can modulate the lipid metabolism and inhibit the formation of fatty liver in cholesterol-fed rabbits.