J Ethnopharmacol. 2001 Aug; 76(3): 223-8.

Neuropharmacological profile of ethnomedicinal plants of Guatemala.

Morales Cifuentes C, GÃ³mez-Serranillos MP, Iglesias I, Villar del Fresno AM, Morales C, Paredes ME, CÃ¡ceres A.

Departamento de FarmacologÃa, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.

We carried out the Irwin's test with some different extracts of the aerial parts of Thidax procumbens L., the leaves of Neurolaena lobata (L.) R. Br., bark and leaves of Byrsonima crassifolia (L.) Kunth. and Gliricidia sepium Jacq. Walp., and root and leaves of Petiveria alliacea L. At dosage of 1.25 g dried plant/kg weight aqueous extracts of bark and leaves of Byrsonima crassifolia (L.) Kunth. and Gliricidia sepium Jacq. Walp. demonstrated the most activity: decrease in motor activity, back tonus, reversible parpebral ptosis, catalepsy and strong hypothermia. These extracts of both plants were assayed for effects on CNS and they caused very significant reductions in spontaneous locomotor activity, exploratory behavior and rectal temperature and they increased the sodium pentobarbital-induced sleeping time.