Fitoterapia. 2001 Jun; 72(5): 487-91.

Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats.

Liu XM, Zakaria MN, Islam MW, Radhakrishnan R, Ismail A, Chen HB, Chan K, Al-Attas A.

Department of Pharmacology and Toxicology, Zayed Complex for Herbal Research &Traditional Medicine, Ministry of Health, 29300 Abu Dhabi, United Arab Emirates. [email protected]

The 10% ethanol extract of the aerial parts of Calligonum comosum (50--400 mg/kg, i.p.) significantly reduced the increase in hind paw oedema induced by carrageenan in rats. Following sub-acute oral administration of the extract (50 and 100 mg/kg, daily for 14 days), a significant anti-inflammatory activity in the cotton pellet model was observed. Pre-treatment with the extract (100, 200 and 400 mg/kg) produced a significant and dose-dependent inhibition to the acute gastric ulcers induced by phenylbutazone, indomethacin, 0.2 N NaOH and 80% ethanol.