Antibakterielle Wirkung von Australischem Teebaumöl gegen verschiedene Pseudomonaden
Journal/Book: Erfahrungsheilkunde. 2001; 50/6: 340-348.
Abstract: Pseudomonades are gram-negative bacteria, which are resistant to many antibiotics. Pseudomonas aeruginosa is an important germ in a hospital, because it can cause various nosocomial infections like wound infections, pneumonias, sepsis, and bronchitis. It is said, that for the topic treatment of germ carriers, in addition to antibiotics and disinfectants, also essential oils with a broad antibacterial effect are potentially suitable. Up to now, there are only contradictory reports about the question, whether essential oils, like for example Australian Tea Tree Oil (TTO), are biologically effective against Pseudomonas aeruginosa and other pseudomonades.Of the tested pseudomonades, only Pseudomonas pickettii, Stenotrophomonas maltophilia and Burkholderia cepacia were susceptible to TTO (MIC: 0,12-0,25TTO). The TTO susceptibility of Pseudomonas aeruginosa was insufficient (MIC: > 4 %). The TTO susceptibility of all tested germs increased clearly, when oxidized, essential oil was used instead of fresh, non-oxidized TTO. In another approach, we have incorporated 5 % TTO into a carbomer gel (Carbopol 941 gel). The TTO Carbopol 941 gel showed a very good antibacterial effect against Pseudomonas aeruginosa and other pseudomonades (M IC: 0,120,5 % TTO).The increased TTO susceptibility of the tested pseudomonades to oxidized TTO and TTO Carbopol 941 gel is explained with an increased permeability of the outer membrane (OM) of the bacterial cell membranes, which is caused by the interaction of the peroxides or the polycationic carbomer gel with the lipopolysaccharide of the OM respectively.