Hunan Yi Ke Da Xue Xue Bao. 2000 Jun; 25(3): 245-7.

[Protective effect of traditional Chinese medicine nao-yi-an granule in experimental rats with hemorrhagic stroke]

Luo TL, Li XQ.

Institute of Combined Traditional Chinese and Western Medicine, Xiangya Hospital, Hunan Medical University, Changsha 410008.

In order to establish a model of intracerebral hemorrhage(ICH), 0.4 U bacterial collagenase was injected stereotaxically into globus pallidus in rats. Neurological deficit score was investigated, and inducible nitric oxide syntahse(iNOS) mRNA was detected in 72 rats. The results showed that: in the group treated by nao-yi-an granule(NYA), the recovery time was shorter than that in other groups, and low concentration nitrite and weak signal of iNOS mRNA were found. It suggests that inhibition of iNOS induction is one of the pharmacological effects of NYA.