Zhongguo Zhong Yao Za Zhi. 2000 Feb; 25(2): 107-10.

[Studies on antitussive, antiasthmatic, expectorant and anti-inflammatory effects of Jin'an kechuan granules]

Chen GL, Wang Y, Wang QM, Liu C, Cheng HJ, Han L.

Department of Pharmacology, Anhui College of TCM, Anhui, Hefei 230038, China.

OBJECTIVE: To study the pharmacologic effect of Jin'an Kechuan granules. METHOD: Routine antitussive, antiasthmatic and expectorant methods were used. RESULT: Jin'an Kechuan granules in the doses of 16, 8, 4 g.kg-1 ig could significantly decrease the frequency of cough caused by ammonia water in mice, and increase the secretion of phenol red from mouse tracheas in a dose-dependent manner. The granules also help increase the threshold voltage to induce cats to cough, prolong the latent period of asthma induced by histamine and acetylcholine mixture, and antagonize the contraction of isolated trachea strips induced by histamine and acetylcholine in guinea pigs. Jin'an Kechuan granules had inhibitory effects on common bacteria in the respiratory tract as well as on the swelling of acute inflammation in mice and rats. CONCLUSION: Jin'an Kechuan granules have antitussive, antiasthmatic, expectorant and anti-inflammatory, antibacterial effects.