Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Oct; 20(10): 747-9.

[Observation on curative effect of acute ischemic cerebrovascular disease treated with different dosage of ligustrazine]

Cai Y, Ren M, Yang R.

Institute of Neurology, Anhui College of TCM, Hefei 230031.

OBJECTIVE: To compare clinical curative effect of acute ischemic cerebrovascular diseases (ICVD) treated with different dosage of ligustrazine and to observe the effect of ligustrazine on hemorrheology. METHODS: Sixty-nine patients with ICVD were randomized into three groups, the Group A, B and C treated with 120 mg, 240 mg and 480 mg of ligustrazine respectively, the clinical curative effect, the changes in nerve function deficit score and hemorrheologic parameters before and after treatment were observed. RESULTS: The clinical curative effect and improvement of hemorrheologic parameters in Group C were better than those in Group A and B significantly (P < 0.05, P < 0.01 respectively). Ligustrazine also showed obvious effect in lowering blood level of fibrinogen in Group C. CONCLUSION: Treatment of acute ICVD with large dose of ligustrazine is good in improving clinical effect and hemorrheology, and without side effect basically.