Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Oct; 20(10): 727-8.

[Chinese drugs for invigorating spleen to remove dampness, activating blood circulation to eliminate turbid in retarding progression of chronic renal failure]

Yu Y, Cui J, Zhang F.

Department of Nephrology, General Hospital of Chengdu Military Region, Chengdu 610083.

OBJECTIVE: To investigate the effect of Chinese drugs (CD) for invigorating Spleen to remove dampness, activating blood circulation to eliminate Turbid in retarding progression of chronic renal failure (CRF). METHODS: Thirty-nine patients with CRF were divided into two groups randomly, 18 patients in the control group were treated with low protein diet and controlling blood pressure and 21 patients in the CD group were treated similarly with that of the control group but with additional CD. Levels of serum creatinine (SCr), blood urea nitrogen (BUN), blood albumin (Alb), cholesterol (CH), triglyceride (TG), high-density lipoprotein (HDL) and hemoglobin (Hb) were checked every 2 months, and the rate of progression of CRF was estimated by slope of the creatinine reciprocal (1/SCr) with time (month). RESULTS: Levels of SCr and BUN in the CD group were significantly lower and HDL markedly higher than those in the control group, P < 0.05. Mean slopes of the creatinine reciprocal with time in the two groups was significantly different, P < 0.01. CONCLUSION: Additional CD treatment based upon the protein diet and controlling blood pressure could retard the progression process of CRF evidently.