Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Apr; 20(4): 251-4.

[Clinical and experimental study on yun'an granule in treating threatened abortion]

Zhang J, Zhang Y, Liu G.

Shanxi Provincial Academy of Traditional Chinese Medicine, Taiyuan (030012).

OBJECTIVE: To observe the effect of Yun'an Granule (YAG) on threatened abortion. METHODS: Five hundred and eighty patients were divided randomly into the treatment group and the control group. The effect of YAG in treating 580 patients was observed by double-blinded method and compared with that treated with progesterone (50 cases) or Shoutai Pill (50 cases) in the control group. And experimental study was conducted also. RESULTS: Clinical results showed that the therapeutic effective rate in YAG (96.9%) was obviously higher than that in the control group (56.0% for progesterone and 86.0% for Shoutai pill), the difference between them was significant (P < 0.05). Experimental results also showed that the YAG had fetus protective effect on the acupuncture or oxytocin induced threatened abortion model in rats, which was better than that of progesterone (P < 0.05). The mean weight of baby rats and placenta delivered by the mother rats which taken YAG were heavier than those which were untreated or treated by progesterone (P < 0.05). In addition, YAG could inhibit the normal or oxytocin stimulated contraction of rat's isolated uterus. CONCLUSION: YAG has good effect in treating threatened abortion and without any adverse effect on fetus.