Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Jun; 20(6): 447-9.

[Observation on dynamic changes of serum procollagen III, hyaluronic acid and laminin in rats with hepatic fibrosis treated with Hujin pill]

Huang Z, Li Q, Wang Z.

College of Chinese Materia Medica, Guangzhou University of Traditional Chinese Medicine, Guangzhou (510405).

OBJECTIVE: To study the dynamic changes of serum procollagen III (PCIII), hyaluronic acid (HA) and laminin (LN) in rats with hepatic fibrosis treated with Hujin pill (HJP). METHODS: The classic model of hepatic fibrosis induced by CCl4 were used in the observation. The serum PCIII, HA and LN were determined by radioimmunoassay (RIA). RESULTS: HJP could reduce the serum HA, LN content significantly, as compared with the control group, the difference was significant (P < 0.05, P < 0.01). Its long-term therapeutic effect was better than that of colchicine. It could maintain the serum PCIII stable in hepato-fibrotic stage (9-12 weeks), as compared with the normal control group, the difference was insignificant (P > 0.05). CONCLUSION: HJP could retard the liver fibrosis, and has good preventive and therapeutic effect on liver fibrosis in rats.