Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Jun; 20(6): 438-40.

[Contrast observation on preventive effect of different traditional Chinese medicine treatments on coronary artery ligation induced myocardial ischemia in rats with diabetes mellitus]

Li S, Xiong M, Lin A.

Guangzhou Traditional Chinese Medicine University, Guangzhou (510407).

OBJECTIVE: To compare the preventive effect of different TCM treatment on coronary artery ligation induced myocardial ischemia in rats with diabetes mellitus. METHODS: Model rats of diabetes mellitus induced by streptozotocin were used to form myocardial ischemia models by coronary artery ligation, which were treated by modified Taohe Chengqi Decoction (TCD) and different combination of its ingredients. The effect of different TCM treatment on ischemic area, arrhythmia rate and T-wave in electrocardiogram, and 2 hrs postoperational survival rate were observed. RESULTS: Effect of reducing ischemic area and raising survival rate (P < 0.05, P < 0.01) showed in all the groups treated by different TCM treatment, especially in the group treated with comprehensive TCM. Obvious improvement on T-wave revealed in the groups treated with TCD and comprehensive TCM (P < 0.05, P < 0.01). CONCLUSION: Invigorating Qi and Nourishing Yin, Expelling Heat by purgation and accentuating on activating blood circulation is an effective method of TCM in treating and preventing diabetic coronary heart disease.