Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Jun; 20(6): 430-2.

[Influence of safflower injection on hemorheology of patients of chronic cor pulmonale during acute attack]

Jin Y, Xu D, Xu W.

Xinhua Hospital, Shanghai Second Medical University, Shanghai (200092).

OBJECTIVE: To study the effect of safflower injection (SI) on hemorheology and fibrinolytic system in treating patients of chronic cor pulmonale during acute attack. METHODS: Sixty patients were divided into two groups, 30 in each group. Both groups were treated with conventional therapy including anti-inflammatory, relieving cough and reducing sputum, cardial, diuretic and continuous low-flow oxygen inhalation. For the SI group, additional two courses of SI injection was given intravenously for 10 days as one course with an interval of 5 days between courses. The clinical therapeutic effect in the two groups and effect of treatment on hemorheology and fibrinolytic function were observed. RESULTS: The total effective rate in the SI group was 86.7% and that in the control group was 63.3%, the difference between the two groups was significant (P < 0.05). After treatment, in the SI group, the high- and low-shear whole blood viscosity, plasma viscosity, erythrocyte agglutination index, hematocrit and fibrinogen lowered obviously, as compared with before treatment (P < 0.01 or P < 0.05), and the improvement in hemorrheologic property was better than that in the control group significantly (P < 0.05). The blood activities of anti-thrombin III, plasminogen and tectotype profibrinolytic activating factor were all higher than those in the control group (P < 0.05, P < 0.01). And SI showed more potent effect in improving anti-coagulation and fibrinolytic function of patients than that of the control (P < 0.05). CONCLUSION: SI is an effective drug for treatment of hypercoagulability status in acute stage of chronic cor pulmonale, and is worthy of clinical application.