Chest Surg Clin N Am. 2000 Nov; 10(4): 663-90, v.

Prevention of lung cancer. The new millennium.

Kim ES, Hong WK, Khuri FR.

Department of Thoracic/Head and Neck Medical Oncology, M. D. Anderson Cancer Center, University of Texas, Houston, USA.

Lung cancer is the leading cause of cancer-related death worldwide and in the United States surpassing breast, prostate, and colon cancer. Treatment of this disease over the past 2 decades has advanced incrementally as survival rates have improved only slightly. Alternate approaches to this deadly disease include an emphasis on prevention such as smoking cessation. Chemoprevention has introduced a new arena of treatment options for early intervention in lung carcinogenesis. The use of molecularly targeted therapeutic and biologic agents constitutes novel strategies for lung cancer prevention in the new millennium.