Fitoterapia. 2000 Aug; 71 Suppl 1(): S131-7.

Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage.

Capasso R, Pinto L, Vuotto ML, Di Carlo G.

Department of Pharmaceutical Sciences, Via Ponte Don Melillo, 84084, Fisciano, Salerno, Italy.

This study examines the anti-ulcerogenic activity of eugenol, a natural compound obtained from many natural sources. Gastric ulcers, induced by administration of two ulcerogenic agents, i.e. platelet activating factor (PAF) and ethanol, were dose-dependently and significantly reduced by eugenol (10-100 mg/kg, p.o.) pre-treatment. Eugenol was able to reduce not only the number of ulcers but also the gravity of lesions.