Fitoterapia. 2000 Aug; 71 Suppl 1(): S29-37.

Grapefruit: the last decade acquisitions.

Tirillini B.

Istituto di Botanica, UniversitÃ di Urbino Via Bramante, 28-61029, Urbino, Italy.

This review reports the last decade acquisitions on grapefruit. New coumarins and limonoids were isolated and characterised. The bioavailability of many drugs was tested with grapefruit juice (GJ) coadministration; the inhibition on cytochrome P450 seems due to a synergic action between flavonoids and coumarins. Antimicrobial, antifeeding, insecticidal, and antitumour activities were also reported.