Phytomedicine. 2000 Apr; 7(2): 117-21.

Effect of Maytenus aquifolium extract on the pharmacokinetic and antiinflammatory effectiveness of piroxicam in rats.

Kimura E, Albiero AL, Cuman RK, Caparroz-Assef SM, Oga S, Bersani-Amado CA.

Department of Pharmacy and Pharmacology of the MaringÃ¡ State University, Brazil.

This study explored the interference by Maytenus aquifolium leaves hydroalcoholic (MALHE) extract, administered orally, on the pharmacokinetic and antiinflammatory activity of piroxicam in rats. The results showed no significant difference in piroxicam bioavailability with simultaneous application of MALHE. MALHE also had no effect on the inhibitory effect of piroxicam on inflammatory processes induced by carrageenan and complete Freund adjuvant.