A replication study on P300 single trial analysis in schizophrenia: confirmation of a reduced number of 'true positive' P300 waves

Author(s): Roschke, J., Grozinger, M., Mann, K.

Journal/Book: J Psychiat Res. 2000; 34: the Boulevard Langford Lane, Kidlington, Oxford Ox5 1GB, England. Pergamon-Elsevier Science Ltd. 255-259.

Abstract: A single trial analysis of event-related potentials (auditory odd-ball paradigm) of 20 schizophrenics was performed in comparison to matched healthy controls. The purpose of the study was to test the hypothesis that in schizophrenia the well-known P300 amplitude reduction of averaged event-related potentials is due to fewer elicited single trial P300 waves. The results of the present study support this finding of our previous exploratory investigation and point to the view that schizophrenics reveal basal disturbances in information processing due to inadequately elicited electrophysiological responses to target stimuli.

Note: Article Roschke J, Univ Mainz, Dept Psychiat, Untere Zahlbacher Str 8, D-6500 Mainz, GERMANY

Keyword(s): P300; schizophrenia; single trial analysis; auditory event-related potentials; information processing; EVENT-RELATED POTENTIALS; SIGNAL-DETECTION-THEORY; EVOKED-POTENTIALS; DEPRESSION; MEMORY

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