In search of a deep psychobiology of hypnosis: Visionary hypotheses for a new millennium

Journal/Book: Amer J Clin Hypn. 2000; 42: 33 W Grand Ave, Ste 402, Chicago, IL 60610, USA. Amer Soc Clinical Hypnosis. 178-207.

Abstract: This search for the deep psychobiological foundations of hypnosis begins with a review of some of the paradoxes of historical hypnosis and the impasse of current theory. It is proposed that further progress requires a deeper investigation of how psychosocial cues can modulate the mechanisms of healing at the CNS, autonomic, neuroendocrine and cellular-genetic levels. The dynamics of hypnotic communication and healing from the cognitive-behavior level to the cellular-genetic are outlined in four stages: (1) Information transduction between the experiences of consciousness and the limbic-hypothalamic-pituitary system; (2) The psychosomatic network of messenger molecules and their receptors; (3) The immediate early gene protein cascade; and (4) State dependent memory, learning and behavior. Neuroscience research is outlined for its contributions to a mathematical model of how a psychobiological approach to the therapeutic applications of hypnosis and the placebo response could facilitate neurogenesis in the human hippocampus and healing at the cellular-genetic-protein level throughout the body. A series of ten hypotheses is proposed as a guide for theory and research in therapeutic hypnosis utilizing DNA chip technology in the new millennium.

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Keyword(s): PERIPHERAL-BLOOD LEUKOCYTES; HYPNOTIC-SUSCEPTIBILITY; POTENTIAL AMPLITUDES; BIOLOGICAL RHYTHMS; MEMORY STORAGE; STRESS; VARIABILITY; MODULATION; EXPRESSION; SECRETION

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