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July 2021

Olfactory event-related potentials and aging: normative data

Author(s): Morgan, C. D., Geisler, M. W., Wetter, S., Covington, J. W., Madowitz, M. D., Nordin, S., Polich, J. M.

Journal/Book: Int J Psychophysiol. 2000; 36: PO Box 211, 1000 AE Amsterdam, Netherlands. Elsevier Science Bv. 133-145.

Abstract: Unlike the clinical usages of evoked potentials (e.g. Brain stem auditory evoked potentials for the assessment of auditory function), normative data for the olfactory event-related potential (OERP) have been unavailable. The principal objective was to establish normative data across the human life span for OERPs with a given set of parameters. Participants were 140 persons from seven age groups (16-19, 20-29, 30-39, 40-49, 50-59, 60-69 and 70-79 years of age), with equal numbers of males and females, screened for nasal health and dementia. The odor stimulus was amyl acetate, presented at nasal temperature in a humidified airstream delivered by an air-dilution olfactometer at a constant flow rate, using a 60-s inter-stimulus interval. OERPs were recorded at Fz, Cz, and Pz electrode sites, amplified and averaged over trials. Amplitudes of the N1/P2 and P3 and latencies of the P2 and P3 were analyzed. Processing speed decreased at a constant rate over decades for the sensory (P2 latency) as well as cognitive (P3 latency) components. Decline in amplitude over decades was also apparent. Normative data will be useful in research on olfactory function and in clinical assessment of olfactory functional status.

Note: Article Murphy C, Univ Calif San Diego, San Diego State Univ, San Diego Joint Doctoral Program, 6363 Alvarado Ct, Suite 101, San Diego,CA 92120 USA

Keyword(s): olfactory event-related potentials; aging; life span; latency; amplitude; normative data; ALZHEIMERS-DISEASE; EVOKED-POTENTIALS; ODOR IDENTIFICATION; RECOGNITION MEMORY; AUDITORY-STIMULI; P300; AGE; SMELL; YOUNG; PROBABILITY

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