Which temperamental characteristics are associated with substance use in subjects with psychotic and mood disorders?

Author(s): Verdoux, H.

Journal/Book: Psychiat Res. 2000; 93: Customer Relations Manager Bay 15, Shannon Industrial Estate CO, Clare, Ireland. Elsevier Sci Ireland Ltd. 63-72.

Abstract: The aim of this study was to assess the associations between substance use disorders and temperamental characteristics in subjects with non-affective psychotic disorders or mood disorders. Consecutively hospitalized patients were interviewed with a structured diagnostic interview to define DSM-IV diagnoses, including those of substance use. Temperamental characteristics were measured using the Sensation-Seeking Scale (SSS), the Barratt Impulsivity Scale (BIS) and the Physical Anhedonia Scale. Inpatients (n = 103) with non-affective psychotic disorders (n = 45) or mood disorders (n = 58) were included. Among these patients, 25.2% presented with a lifetime (LT) history of alcohol abuse/dependence and 23.3% presented with a LT history of cannabis abuse/dependence. A LT history of alcohol misuse was independently associated with higher scores at the 'experience seeking' and 'disinhibition? subscales of the SSS. A LT history of cannabis misuse was independently associated with higher scores on the 'disinhibition' subscale of the SSS and the 'non-planning activity' subscale of the BIS. These results suggest that sensation-seeking and impulsivity are temperamental characteristics that may favor substance use in patients with psychotic or mood disorders, independently from categorical diagnoses.

Note: Article Verdoux H, Univ Victor Segalan Bordeaux 2, Dept Psychiat, Hop Charles Perrens, 121 Rue Bechade, F-33076 Bordeaux, FRANCE

Keyword(s): cannabis; alcohol; sensation-seeking; impulsivity; anhedonia; psychotic disorder; affective disorder; ADULT CHRONIC-PATIENTS; SENSATION-SEEKING; DRUG-ABUSE; SCHIZOPHRENIA; ALCOHOL; COMORBIDITY; IMPULSIVITY; ANHEDONIA; RELAPSE; SCALES

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