Neurocognitive correlates of stereotactic thalamotomy and thalamic stimulation in parkinsonian patients

Author(s): Wester, K.

Journal/Book: Brain Cognition. 2000; 42: 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. Academic Press Inc. 231-252.

Abstract: In the present paper we have reviewed five different studies that relate to neuropsychological consequences of stereotactic thalamotomy and thalamic stimulation in patients with Parkinson's disease. The neuropsychological results are in a strict sense confined to thalamotomy and thalamic stimulation, although the more general message of the importance of investigating cognitive functions before and after surgery applies to other stereotactic techniques for surgical treatment of movement disorders as well. It is argued in the paper that stereotactic thalamotomy provides a unique model for basic research on the neuropsychology of the thalamus, while in return, neuropsychological tests for cognitive dysfunction after surgery may be the most important clinical follow-up. Three general conclusions seem warranted from the data. (1) Parkinsonian patients are impaired on a range of cognitive functions, including language processing, memory, and executive functions. (2) Stereotactic thalamotomy does not further impair the patient; instead, we observed improvement on some tests, particularly verbal memory. (3) In general, there does not seem to be a laterality effect, depending on which side the thalamotomy lesion is applied. An exception to this are dichotically presented simple speech sounds and autonomic responses. In both instances, left-sided brain stimulation produced enhanced performance, while lesioning the left thalamus impaired dichotic listening performance. Finally, we present a new hypothesis for a mechanism behind the thalamotomy effect, based in part on changes in arousal thresholds.

Note: Article Hugdahl K, Univ Bergen, Dept Biol & Med Psychol, Arstadveien 21, N-5009 Bergen, NORWAY

Keyword(s): deep brain stimulation; cognition; neuropsychology; Parkinson's disease; stereotaxy; thalamotomy; thalamus; MEMORY DEFICITS; DISEASE; LANGUAGE; NUCLEUS; ORGANIZATION; ATTENTION; CIRCUITS; TREMOR

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