Immunization and the American way: 4 childhood vaccines

Journal/Book: Amer J Public Health. 2000; 90: 1015 Fifteenth St NW, Washington, DC 20005, USA. Amer Public Health Assoc Inc. 199-207.

Abstract: Children immunization constitutes one of the great success stories of American public health ion the 20th century. This essay provides a historical examination of this topic through 4 particularly important examples: diphtheria, pertussis, polio and measles. Each case study illustrates hoe new vaccines have posed unique challenges related to basic science, clinical trial methodology, medical ethics, and public acceptance. A brief comparison of Great Britain, however, suggests an underlying unity connecting all 4 examples. Whereas the British led the way in introducing formal clinical trial methodology in the field of immunization development, the Americans excelled in the rapid translation of laboratory knowledge into strategies suitable for mass application. Although this distinction appears to have diminished in recent years, it offers insight into the sources of creativity underlying American vaccine development and the corresponding difficulties sometimes created for utilizing vaccines' fruits rationally.

Note: Article Baker JP, Duke Univ, Med Ctr, Dept Pediat, Box 3675, Durham,NC 27710 USA

Keyword(s): DIPHTHERIA

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