Zhongguo Zhong Yao Za Zhi. 1999 Feb; 24(2): 104-6, 127.

[Effect of bushenjiannao 1 decoction on learning and memory functions and anti-fatigue ability in mice]

Li B, Li L, Zhang L, Cheng T, Li Z, Liao F, Li W.

Xuanwu Hospital, Beijing Brain Aging Key Laboratory, Beijing 100053.

OBJECTIVE: To observe the anti-dementia effect of Bushenjiannao 1 decoction on mice. METHOD: The learning and memory tests were realized with a water maze on the learning and memory impact of mice induced by scopolamine and cycloheximide. The effect of Bushenjiannao 1 decoction on the independent activity and anti-fatigue ability of mice were also investigated. RESULT: Bushenjiannao 1 decoction used at a medium dose of 15 g crude drug/kg and a higher dose of 45 g crude drug/kg could significantly improve the learning and memory abilities of mice injected with scopolamine. Higher doses could improve these abilities of mice injected with cycloheximide, and also improve the anti-fatigue ability of mice. No significant differences were observed in the independent activity of mice between the groups. CONCLUSION: Bushenjiannao 1 decoction helps improve the learning and memory abilities and enhance the anti-fatigue ability, but has no effect on excitability of the central nervous system.