Zhongguo Zhong Yao Za Zhi. 1999 Oct; 24(10): 624-6, 640.

[Effects of Rg1 on calcium channel of guinea pig ventricular myocytes]

Zhang B, Jin S, Kuang X, Yao W, Xia G, Jiang M.

ICU, Hospital of Chinese Traditional Medicine of Guangdong Province, Fu Shan 528000.

OBJECTIVE: To evaluate the effect of Rg1 (purified saponin of Panax notoginseng) on L-Ca2+ channel of guinea pig ventricular myocytes. METHOD: The whole-cell patch clamp recording technique. RESULT: When the holding potential was kept at -40 mV, and the cell was depolarized to +40 mV for 150 ms at a frequency of 0.5 Hz.Rg1 10 mumol.L-1 and 30 mumol.L-1 could not reduce Bay K 8644 and nifedipine-sensitive L-type Ca2+ inward current (P > 0.05, n = 5). CONCLUSION: Rg1 should not be a Ca2+ channel antagonist.