Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Oct; 19(10): 607-9.

[Efficacy of Chinese recipes of replenishing kidney and activating blood circulation in female rats with osteoporosis induced by ovariectomy]

Zhang R, Chen K, Lu D.

First Affiliated Hospital of Medical College, Jinan University, Guangzhou (510630).

OBJECTIVE: To investigate the efficacy of Chinese recipe of replenishing Kidney and activating blood circulation (RKABC) in female rats with osteoporosis induced by ovariectomy. METHODS: Fifty female SD rats at 12 months of age were chosen, and were divided into 5 groups; control, model, model plus nylestriol, RKABC (high dose) and RKABC (low dose). The model of osteoporosis was established by ovariectomy in rats for 12 weeks, and then was given different kinds of liquid and administered approximately for 12 weeks. General bone mineral density (GBMD), femur bending strength (FBS), serum-BGP and urine-Hyp/Cr were measured. RESULTS: GMBD, FBS in 3 treatment groups were significantly higher than those in the model group (P < 0.05), but lower than those in the normal control group (P < 0.05); GBMD, FBS in 2 RKABC groups were slightly higher than those in nylestriol's group (P > 0.05). Compared with model group, levels of serum BGP in 2 RKABC groups increased (P < 0.05) and in RKABC (H) treatment group increased almost the same as those in the control group (P > 0.05). In comparison with model group, levels of U-Hyp/Cr in 3 treatment groups decreased (P < 0.05, P < 0.01) but 2 RKABC treatment groups still significantly higher than those in the normal control group (P < 0.05). CONCLUSION: It indicated that RKABC could control osteoporosis in female rats induced by ovariectomy and seems to promote bone formation.