J Ethnopharmacol. 1999 Dec; 68(1-3): 205-8.

Studies on antidiarrhoeal activity of Punica granatum seed extract in rats.

Das AK, Mandal SC, Banerjee SK, Sinha S, Das J, Saha BP, Pal M.

Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta, India.

Methanol extract of Punica granatum seed was evaluated for antidiarrhoeal activity against different experimental models of diarrhoea in rats. P. granatum seed extract treated animals showed significant inhibitory activity against castrol-oil induced diarrhoea and PGE2 induced enteropooling in rats. The extract also showed a significant reduction in gastro-intestinal motility in charcoal meal test in rats. The results obtained established the efficacy of P. granatum seed extract as an antidiarrhoeal agent.