Schweiz Rundsch Med Prax. 1999 Sep; 88(37): 1475-80.

[Clinical efficacy and tolerance of the hypericum special extract LI 160 in depressive disorders--a drug monitoring study]

Holsboer-Trachsler E, Vanoni C.

Psychiatrische Universit�tsklinik, Basel.

PATIENTS AND METHODS: 647 patients suffering from mild to moderate depression treated for 6 weeks with hypericum extract LI 160 (Jarsin 300), 1 tablet t.i.d. RESULTS: The condition of the patients improved in 75% (primary endpoint). The von Zerssen depression score decreased from 19.8-21.2 (95%-CI) at base-line to 8.1-9.3 at week 6 (p < 0.001). All symptoms were improved at week 3 and further at week 6. The condition improved somewhat slower in patients older than 65 years. The severity of the depression did not appear to have an effect on the outcome. Adverse events were reported by 17% of the patients (gastrointestinal 10%). These were mostly mild or moderate. Tolerance was rated in 89% as satisfactory or better.