Int J Immunopharmacol. 1999 Feb; 21(2): 115-20.

Immunoprotective effect of IM-133.

Mitra SK, Gupta M, Suryanarayana T, Sarma DN.

R&D Centre, The Himalaya Drug Company, Makali, Bangalore, India.

We studied the immunoprotective effect of IM-133, a poly-herbal formulation, against E. coli-induced intra-abdominal sepsis. Treatment with IM-133 afforded protection against the septic shock induced mortality. The in vivo treatment has enhanced nitric oxide production and phagocytic ability against C. albicans by peritoneal macrophages in Balb/c mice. The protective effect of IM-133 appears to be by virtue of its immunomodulatory activity and finds application in the clearance of intra-cellular pathogens.