Immunopharmacol Immunotoxicol. 1999 Feb; 21(1): 163-74.

Effect of Kumhwang-San on anaphylactic reaction in a murine model.

Kim HM, Yang DJ.

Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, South Korea.

We investigated the effect of Kumhwang-San on anaphylactic reaction. Kumhwang-San dose-dependently inhibited mast cell-mediated systemic anaphylactic reaction induced by compound 48/80. Kumhwang-San significantly inhibited plasma histamine levels induced by compound 48/80. Kumhwang-San dose-dependently inhibited histamine release from the rat peritoneal mast cells activated by compound 48/80 or substance P. The level of cAMP in rat peritoneal mast cells, when Kumhwang-San was added, transiently and significantly increased about 3-fold compared with that of basal cells. These results suggest that Kumhwang-San will be beneficial in the treatment of anaphylactic reaction.