The CCK-A receptor gene possibly associated with auditory hallucinations in schizophrenia

Author(s): Hemmings, G. P.

Journal/Book: Eur Psychiat. 1999; 14: 23 Rue Linois, 75724 Paris Cedex 15, France. Editions Scientifiques Medicales Elsevier. 67-70.

Abstract: In this study, a Pstl polymorphic site with two individual alleles, namely A1 and A2, was identified within the boundary between intron 1 and exon 2 of the cholecystokinin (CCK) type A receptor gene. The Pstl polymorphic site was used as a genetic marker to study its association with psychotic symptoms in schizophrenia. A significant difference in allelic frequency was found between schizophrenic patients with and without auditory hallucinations (chi(2) = 6.26, df = 1, P = 0.012), and the odds ratio for the allelic association was 2.21 (95% Cl 1.18-4.15) with an attributable fraction of 0.1. The frequency of A1-A1 and A1-A2 genotypes showed a significant excess in schizophrenic patients with auditory hallucinations as compared to those without such symptoms (chi(2) = 5.45, df = 1, P = 0.02), and the adds ratio for the genotypic association was 2.27 (95% Cl 1.13-4.57) with an attributable fraction of 0.177. The haplotype-based haplotype relative risk (HHRR) test revealed a significant difference between transmitted and non-transmitted alleles in nuclear families of schizophrenic patients with auditory hallucinations (chi(2) = 4.54, df = 1; P = 0.033) but not in those of schizophrenic patients without them, The present study suggests that the CCK-A receptor gene may be associated with auditory hallucinations in schizophrenia.

Note: Article Wei J, Schizophrenis Assoc Great Britain, Inst Biol Psychiat, The Crescent, Bangor LL57 2AG, Gwynedd, WALES

Keyword(s): auditory hallucination; cholecystokinin (CCK) receptor; gene; polymerase chain reaction (PCR); restriction fragment length polymorphisms (RFLPs); schizophrenia; CHOLECYSTOKININ; DOPAMINE; VARIANT; CORTEX

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