Co-distribution of sensory gating and impaired niacin flush response in the parents of schizophrenics

Journal/Book: Schizophr Res. 1999; 40: PO Box 211, 1000 AE Amsterdam, Netherlands. Elsevier Science Bv. 49-53.

Abstract: Complex illnesses may result from the interaction or addition of multiple factors. We examined the familial co-distribution of two abnormalities common in schizophrenia: impaired auditory sensory gating and impaired flush response to niacin. In ten families, the obligate carrier parent had sensory-gating deficits, while eight of the ten parents without a family history of schizophrenia had impaired flush response. No parents had both deficits. The data are consistent with a theory suggesting the interaction of these two factors in some cases of schizophrenia.

Note: Article Waldo MC, Univ Colorado, Hlth Sci Ctr, Dept Psychiat, 4200 E 9th Ave, Box C268-16, Denver,CO 80262 USA

Keyword(s): fatty acid metabolism; genetics; niacin flush response; schizophrenia; sensory gating; FATTY-ACID COMPOSITION; HIPPOCAMPAL VOLUME; SKIN FLUSH; PLASMA; DEFICITS; METABOLISM; LINKAGE; TWINS

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