The role of genetics in autism

Journal/Book: Infant Young Children. 1999; 12: 7201 Mckinney Circle, Frederick, MD 21704, USA. Aspen Publ Inc. 55-63.

Abstract: Evidence for the hypothesis that genetic factors play a significant role in the susceptibility for autism is reviewed. This evidence comes from three sources: (1) chromosomal abnormalities associated with autism; (2) single gene disorders associated with autism; and (3) twin and family studies of autism. The rationale for and the design of genetics studies of autism currently underway are described. Results from these recent genetic investigations that include candidate gene studies, association studies, and full genome screen studies are reviewed. To date, these investigations have failed to locate any genes having a major effect on the susceptibility for autism. Continuing research efforts, using a variety of approaches, a-ill be needed to further our understanding of the role of genetic factors in autism.

Note: Article Spiker D, Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford,CA 94305 USA

Keyword(s): autism; genetic studies; genome screen; multiplex families; SEROTONIN TRANSPORTER; DIAGNOSTIC INTERVIEW; MULTIPLEX FAMILIES; DISORDERS; LINKAGE; POWER

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