Medications and characteristics of drugs causing ototoxicity

Journal/Book: Volta Rev. 1999; 99: 3417 Volta Place NW, Washington, DC 20007, USA. Alexander Graham Bell Assoc For The Deaf. 195-203.

Abstract: In essence, any medication that enters the confines of the inner ear can be toxic and destroy the structures of hearing. All aminoglycosides are ototoxic to varying degrees; some are cochleotoxic, while others produce vestibular ototoxicity Hearing loss secondary to aminoglycosides ototoxicity is always sensorineural in nature, affecting primarily the high frequencies and progressing to involve all frequencies. Other medications that may produce ototoxicity include loop diuretics, such as furosemide and ethacrynic acid, quinidine, salycilates, and certain chemotherapeutic agents such as cis-platinum.

Note: Article Pappas DG, Pappas Ear Clin, Birmingham,AL USA

Keyword(s): CHILDREN

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