Pharmahuasca: Human pharmacology of oral DMT plus harmine

Journal/Book: J Psychoactive Drug. 1999; 31: 409 Clayton St, San Francisco, CA 94117, USA. Haight-Ashbury Publ. 171-177.

Abstract: A summary is presented of human self-experiments or psychonautic bioassays of pharmahuasca-capsules containing crystalline N,N-dimethyltryptamine (DMT) plus harmine, as well as combinations of other psychoactive tryptamines with other beta-carbolines. The 1967 Holmstedt-Lindgren hypothesis of the ayahuasca effect-oral psychoactivity of DMT consequent to monoamine-oxidase (MAO) inhibition from simultaneous ingestion of beta-carbolines-has been confirmed by eight self-experimenters. Results of a total of some 70 bioassays are summarized and the literature on this subject is reviewed (with 66 references and one table).

Note: Article Ott J, Nat Prod Co, Apartado Postal 532, Xalapa, Veracruz, MEXICO

Keyword(s): ayahuasca; beta-carbolines; N,N-dimethyltryptamine; harmine; 5-methoxy-N,N-dimethyltryptamine; monoamine-oxidase-inhibitors (MAOI); DOSE-RESPONSE; N,N-DIMETHYLTRYPTAMINE; TRYPTAMINE; AYAHUASCA; PLANTS

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